Pharmacology of the lower urinary tract: update on LUTS treatment

Update on Lower Urinary Tract Symptoms

Management of incontinence is forever changing, evolving as our understanding of the pathophysiology improves. It sometimes feels like a sand castle, as the principles of therapy of yesterday are replaced by new modalities, without leaving a trace of treatments in which we so firmly believed. This special issue of TheScientificWorldJOURNAL: TSW Urology was aimed at new treatments, including ter...

Cold Stress Induces Lower Urinary Tract Symptoms (LUTS)

Cold stress due to whole body cooling at low environmental temperatures exacerbates lower urinary tract symptoms (LUTS) such as urinary urgency, nocturia, and residual urine. We established a model system using healthy conscious rats to explore the mechanisms of cold stress-induced detrusor overactivity. In this review, we summarize the basic findings revealed by this model. Rats that are quick...

Guidelines on the Management of Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO)

Osteopathic manipulative treatment (OMT) for lower urinary tract symptoms (LUTS) in women.

BACKGROUND Because of its prevalence and impact on women's well-being, and its high financial costs, female LUTS is an important health problem that requires serious attention from health professionals. OBJECTIVE The objective of this review was to determine the clinical effects of osteopathic treatment on female lower urinary tract disorders. DATA SOURCES A systematic literature search was...

Basic Pharmacology of Botulinum Toxin in the Lower Urinary Tract

Neurotransmitters formed in the cytosol of presynaptic nerve endings are enclosed in transport vesicles, which are then transported toward plasma membrane. Through interaction with SNARE proteins, transport vesicles fuse with plasma membrane to release neurotransmitters into the synaptic space. SNARE proteins are targets of botulinum toxins (BoNTs) and tetanus toxin. All types of BoNTs consist ...